Filmed at the CPM's event 'Personalised Medicine in Practice: Advances in Reproductive Science' on 7th March 2017, Erin Greaves gives her talk 'Animal Models in Reproductive Health'. Erin Greaves obtained her PhD in 2009 in Developmental Biology from Leeds University. Erin carried out her postdoctoral training in (what was then) the MRC Human Reproductive Sciences Unit with Professor Philippa Saunders at Edinburgh University during which she developed an innovative mouse model of endometriosis. In 2014 she was awarded a prestigious MRC Career Development Award and in 2015 was appointed as a Principal Investigator at the MRC Centre for Reproductive Health, Edinburgh. Along with Philippa Saunders and Andrew Horne, Erin leads the research at EXPPECT Edinburgh, a Centre focusing on excellence in pelvic pain and endometriosis care and treatment. Erin’s research focuses on the pathophysiological processes that lead to endometriosis-associated pain, with a particular focus on the role of macrophages.

Centre for Personalised Medicine

Animal Models in Reproductive Health

Filmed at the CPM's event 'Personalised Medicine in Practice: Advances in Reproductive Science' on 7th March 2017. Dr. Patricia Diaz Gimeno is graduated in Biological Science focused on Genetics (2006) with Excellence Award (2007) and a Doctor in Biomedicine by the Department of Pediatrics, Obstetrics and Gynaecology at Valencia University (2011). She achieved her PhD by researching on endometrial receptivity transcriptomics signature as biomarker and its applicability to evaluate human endometrial receptivity in the clinical practice. Dr. Patricia has also worked intensively for the translation of endometrial transcriptomics as a diagnostic method. She reached a deep specialisation in high throughput technologies (microarrays and NGS) and its related functional genomics analysis after her postdoctorate at Príncipe Felipe Research Centre in the Genomics and Bioinformatics department (2011-2013). Since 2013 she has set up the Bioinformatics Lab at FIVI and has improved the knowledge of Window Of Implantation patient stratification using transcriptomics as gold standard and machine learning predictors. In addition, she has applied a systems genomics perspective for researching the molecular basis of menstrual cycle and endometrial factor subfertilities.

Personalised Medicine in Endometrial Factor Evaluation: Transcriptomics and Machine Learning Predictors

Filmed at the CPM's event 'Personalised Medicine in Practice: Advances in Reproductive Science' on 7th March 2017, Michael Parker gives his talk 'Ethical Issues in Research in Reproductive Medicine'. Professor Michael Parker is the Director of the Ethox Centre and of the newly established Wellcome Centre for Ethics, Innovation, Globalisation and Medicine. Both Centres are located in the Big Data Institute Building at the University of Oxford’s Old Road Campus. Michael is also the Chair of the Genomics England Ethics Advisory Committee and one of the Directors of the 100,000 Genomes Project. His main research interest is in the ethical issues arising in the clinical and research uses of genomics. Together with partners at the Wellcome Major Overseas Programmes in Kenya, Malawi, South Africa, Thailand and Vietnam, Ethox has a Wellcome Strategic Award to build ethics capacity and conduct research on the ethical issues arising in global health research. This collaboration also has a focus on the ethics of global health research involving genomics and data-sharing.

Ethical Issues in Research in Reproductive Medicine

Filmed at the CPM's event 'Personalised Medicine in Practice: Advances in Reproductive Science' on 7th March 2017, Dagan Wells gives his talk 'The evolution of preimplantation genetic diagnosis: karyomapping and beyond'. Dagan Wells has been actively involved in preimplantation genetic diagnosis (PGD) and the study of human gametes and embryos for almost 25 years. He spent several years at University College London, where he accomplished the first comprehensive chromosome analysis of cells from human embryos in 1998. The following year Dagan moved to the United States and joined Reprogenetics, the world’s largest provider of PGD services, initiating their highly successful single gene PGD program. Dagan later joined the faculty of Yale University Medical School, where he set-up a research laboratory, before returning to the UK in 2007. He is now an Associate Professor at the University of Oxford, based at the Nuffield Department of Obstetrics and Gynaecology. After arriving in Oxford, Dagan established Reprogenetics-UK, a laboratory offering state-of-the-art diagnostic services to IVF clinics, which has grown to become the largest provider of PGD services in the UK. Dagan’s work has led to the publication of over 150 peer-review publications and in the last decade has been shortlisted for seventeen major conference prizes (ASRM and ESHRE), winning nine of them. Dagan is a Fellow of the Royal College of Pathologists and the Royal Society of Biology and currently serves on the Editorial Boards of several international journals.

The Evolution of Preimplantation Genetic Diagnosis: Karyomapping and Beyond

The CPM is an innovative partnership between the Wellcome Trust Centre for Human Genetics and St Anne’s College at the University of Oxford. The Centre contributes to facilitating a more individualised approach to healthcare by providing a focus for multidisciplinary collaboration; enhancing the educational experience of students, academics, clinicians and the public; and facilitating new programmes of research.

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Centre for Personalised Medicine

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