Guest: Caroline Hastings, MD Guest: Raymond Y. Wang, MD Niemann-Pick disease type C (NPC) is an ultra-rare, inherited, neurodegenerative disease with life-threatening complications. Due to its highly variable onset of neurological symptoms throughout one’s lifespan, recognizing and establishing diagnosis for NPC can be challenging for any clinician. That’s why Drs. Caroline Hastings and Raymond Y. Wang join Dr. Jennifer Caudle to help address those challenges with a detailed look at this genetic condition, the factors underlying its variable onset and course, and strategies to improve recognition, cross-specialty communications, and time to diagnosis. Copyright ©2021 Orphazyme A/S. All rights reserved.NP-USA-1492-v1ORPHAZYME is a trademark or registered trademark of Orphazyme A/S.

Focus on Neurology and Psychiatry

Closing Gaps in the Recognition & Detection of Niemann-Pick Disease Type C

Host: Mario R. Nacinovich, Jr., MSc Guest: Paul Orchard, MD Although it only affects about one in 18,000 people, the impacts of adrenoleukodystrophy cannot be underestimated. That’s why Dr. Paul Orchard joins Mario Nacinovich to talk about this rare—and fatal—genetic disease, why it’s often underdiagnosed and confused with other conditions, and how we can treat it once we’ve reached an accurate diagnosis.

Keys to Avoiding an Adrenoleukodystrophy Misdiagnosis

Host: Brian P. McDonough, MD, FAAFP Guest: Kisma Orbovich Improvement is something we’re all constantly chasing, whether it’s in the form of a promotion, a bigger house, or maybe even an ideal weight. So why do we often fail miserably at these attempts to make our lives better? To get to the bottom of this dilemma, Dr. Brian McDonough is joined by Kisma Orbovich, the CEO of Illumination Academy, to reveal the secret to true success and how gratitude may just be the lifehack we’ve been searching for.

Strategies for Success: Exercising Our Mental Muscle

Host: Brian P. McDonough, MD, FAAFP Guest: Teresa Gil, PhD Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

The Lasting Effects of Childhood Sexual Abuse: Fighting the Lifelong Battle

Host: Patricia K. Coyle, MD Guest: Clyde E. Markowitz, MD Please note: This activity is no longer available for continuing education credit. Multiple sclerosis (MS) is one of the leading causes of disability worldwide. As the treatment armamentarium continues to grow, patient involvement in the development of an effective treatment strategy is becoming increasingly important. In this Clinical ExchangesSM activity, leading MS specialists discuss issues of diagnosing MS, initiating treatment, and switching therapies, all in the context of practical shared decision-making techniques demonstrated by their own patients. 

Detangling Difficult Conversations About Multiple Sclerosis: Clinical Exchanges

Host: Andrew Wilner, MD, FACP, FAAN Even with quick thinking and timely action, the chances of a neurosurgeon being able to do more than taking out the bullet, administering antibiotics, and stopping the bleeding isn’t likely, and surviving a bullet to the brain can unfortunately be just the beginning of a patient’s struggles. Focusing on the title story of his book Bullets and Brains, Dr. Andrew Wilner discusses the serious aftermath congresswoman Gabrielle Giffords experienced while recovering from a headshot.

Bits from “Bullets and Brains”: The Challenge of Healing After a Headshot

Host: Andrew Wilner, MD, FACP, FAAN As a follow-up to the Microgravity: A New Risk Factor for Idiopathic Intracranial Hypertension essay he wrote back in 2012, Dr. Andrew Wilner investigates whether there have been any updates on the 27 astronauts who had significant microgravity exposure.

Bits from “Bullets and Brains”: Houston, We Have a (Health) Problem

Host: Matt Birnholz, MD Guest: Wes Ely, MD, MPH After surviving a critical illness, many patients look forward to their lives returning to normal, but unfortunately, that’s not always possible. To uncover the far-reaching impacts of delirium, Dr. Matt Birnholz is joined by Dr. Wes Ely, Professor of Medicine and Co-Director of the Center for Critical Illness, Brain Dysfunction and Survivorship Center at Vanderbilt University’s School of Medicine which focuses on improving the lives and care of patients in the intensive care unit to ensure both physical and cognitive rehabilitation.

Delirium: The Hidden Disorder Plaguing ICU Patients

Host: Brian P. McDonough, MD, FAAFP Guest: David Neagle Is it possible that our environment and experiences have subconsciously programmed our emotional response to the world around us? Joining Dr. Brian McDonough is David Neagle, author of The Millions Within: Tips to Improve Emotional Intelligence, to offer advice on what impacts our emotional intelligence and the changes we can implement to strengthen our own. Produced in cooperation with: 

IQ vs. EQ: Is Emotional Intelligence Just as Important?

Host: Brian P. McDonough, MD, FAAFP In a time when humans walked among wild animals, the fight-or-flight response could've been the difference between eating dinner or being dinner. Today, however, the effect of this stress could be much more problematic for our society. In a review of his findings, Dr. Pratha Dutta joins Dr. Brian McDonough to focus on how our body and immune system react to sympathetic activation and what this might mean for some of your patients. 

Fight or Flight: Understanding Our Body's Response to Adrenaline

Host: Maurice Pickard, MD Guest: Allison Pataki Five months pregnant, on a flight headed for Hawaii, Allison Pataki's life took a sudden turn when she witnessed her husband, Dave Levy, lose consciousness. After an emergency landing and evaluation, Levy was found to have had suffered a rare stroke. When he woke the next day, he had amnesia, leaving the young couple holding onto hope for recovery. True to form, Pataki began to write letters to her husband—letters that became the foundation for Beauty in the Broken Places: A Memoir of Love, Faith, and Resilience.

Beauty in the Broken Places: Memoir of Love, Faith, and Resilience

The Food and Drug Administration (FDA) is warning that the medicine lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body’s infection-fighting immune system. This can cause severe inflammation throughout the body and lead to hospitalization and death, especially if the reaction is not diagnosed and treated quickly. A link to the full communication detailing specific information for health care professionals and a list of FDA-approved GBCAs can be found at www.fda.gov/Drugs/DrugSafety Released 4/25/2018

FDA Warns of Serious Immune Reaction with Seizure/BPD Medicine Lamotrigine (Lamictal)

Host: Brian P. McDonough, MD, FAAFP With a wide spectrum of symptoms, treating depression often becomes frustrating—not only for the patient, but for the primary care physician as well. Joining Dr. Brian McDonough is Dr. Paul Gross, founder of the TMS Center of Lehigh Valley, to address the difficulties of properly identifying depression. Throughout the discussion, Dr. Green also exposes the impactful therapy Transcranial Magnetic Stimulation (TMS), which has been linked to improving other diseases beyond depression. 

Detecting Depression: How to Assess Patients & the Benefits of TMS Treatment

Host: Maurice Pickard, MD Guest: Carl Hart, MD Carl Hart, who grew up in one of Miami’s toughest neighborhoods, escaped a life of crime and drugs and avoided becoming one of the crack addicts he now helps treat as the Chair of the Department of Psychology at Columbia University. His landmark, controversial research is redefining our understanding of addiction and demonstrates how personal experience and scientific study can inform and validate each other for a deeper understanding of human behavior and addiction. Host Dr. Maurice Pickard talks with Dr. Hart, author of the book High Price, about the relationship between drugs and pleasure, choice, and motivation, both in the brain and in society. They explore how his research sheds new light on common ideas about race, poverty, and drugs, and explain why current policies are failing. 

High Price: How A Neuroscientist's Journey of Self-Discovery is Challenging Society's Perception on Drugs

Host: Shira Johnson, MD Guest: Bennett Omalu, MD Many studies have demonstrated long-lasting and even permanent brain damage that can originate from just one concussion. With athletes suffering multiple repeated head traumas due to high-contact sports, the controversies over player safety and long-term health risks remain hot-button issues. Pathologist Dr. Bennett Omalu coined the term "CTE" and published the first evidence for chronic traumatic encephalopathy after autopsying American football players. In this second of a two-part interview, he shares his perspectives on CTE in athletes and the lifelong dangers of contact sports.

Dr. Bennett Omalu on the Dangers of Concussions and CTE

New research and clinical trials yield frequent developments in neuroscience and mental health. ReachMD welcomes an array of leading thinkers who lend their focused expertise to these principles, central to human function and ability.

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Focus on Neurology and Psychiatry

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