Timestamps:00:00 Intro01:02 What are a few of the potential risks and benefits of using social media as a professional? Why should I be doing this and thinking about it?03:31 People can adjust their privacy settings on social media, so why is it important for healthcare professionals and students to behave professionally on social media? 06:08 Some might say that there are several shades of gray when it comes to professionalism. So, what do we need to understand about professionalism on social media?08:44 I understand that you have some things you’ve helped students and faculty navigate social media, can you share a few of those significant challenges with us?13:15 What are a few tips for people just getting started?17:38 What’s your view of professional use of social media?19:58 Outro

Lab Medicine Rounds

Being a professional on social media: Challenges and opportunities

In this episode of Lab Medicine Rounds, Chris Hartley, M.D., Assistant Professor of Laboratory Medicine and Pathology at Mayo Clinic, discusses the topic of cytopathology, and what some of the challenges and advancements are.

Cytopathology: Cases, challenges, and advancements

Disclosure of relevant financial relationship: Dr. Mazepa received honoraria from Sanofi.Timestamps:00:00 Intro00:52 Why is it important for physicians to have some understanding about TTP?04:26 What’s new in this immune TTP area?08:57 If you have a new patient show up, you do caplacizumab and plasma exchange together or are there certain patient populations, like certain characteristics who would or would not get this medication? 11:29 I was wondering if you could elaborate a little bit more about these chronic complications?16:32 Do you think there is a role for repeat testing of ADAMTS13 on these patients in chronic phase, or is that an area that is unknown at this point?18:53 What do you see on the horizon, what do you think the future looks like for TTP?21:36 OutroResources:Stroke and TTP (Hopkins group led by Dr. Shruti Chaturvedi):  https://ashpublications.org/blood/article/134/13/1037/374919/Reduced-ADAMTS13-activity-during-TTP-remission-isCognitive impairment in TTP:(Ohio State and London TTP group collaboration) https://ashpublications.org/blood/article/134/13/1037/374919/Reduced-ADAMTS13-activity-during-TTP-remission-is(OK Registry, Dr. James George) https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.24060

Thrombotic thrombocytopenic purpura (TTP): Why it’s important to understand it

Timestamps:00:00 Intro00:43 Why is it important for physicians to understand about the reversal of these direct oral anticoagulants?03:09 The complications or the bleed rate was a lot less, with these direct oral anticoagulants?03:57 Although there is less severe bleeding, there was a concern by patients and physicians about, if it is severe, what is the plan? 04:51 What have we learned new? Are we learning more about what patient population to use them in, as well as the plans to reverse them?06:10 Can you elaborate a little bit about the idea for weekly monitoring for INR, why is it a big deal? 7:44 Could you give us an example of where it wouldn’t be ideal to do home INR monitoring for a given patient?09:06 Are there updates to what the reversal plans are, and how have they changed recently?12:34 Are there still some challenges that remain for reversing these direct oral anticoagulants?19:54 What do you think the future looks like for anticoagulant reversal? 23:47 OutroResources:https://pubmed.ncbi.nlm.nih.gov/30916798/

Reversal of DOACs: Making critical advancements

Timestamps:00:00 Intro01:10 Why is reference laboratory testing important for physicians and laboratorians to understand?02:00 No lab does all the testing in their own laboratory. Labs can’t really have a whole panel of laboratory tests; it just doesn’t make sense, right?04:39 What have we learned in the last couple years about reference laboratories, how we can best support clinical practice?06:10 Do you have an insight for how that communication goes? 8:46 How might a hospital reach out and partner with their reference laboratory? 11:06 What does the future of reference laboratories look like? What might be in store for us?15:00 Outro Register for Leveraging the Laboratory:www.news.mayocliniclabs.com/2021levlab

Rapid reference laboratory development

Timestamps:00:00 Intro01:15 Why are external rotations in pathology important from the student perspective?03:51 Do you get to understand the particulars of a program or maybe what kind of questions you might be asking when you later interview because you do a rotation? 05:03 What is unique from an international perspective? 07:53 Can you compare and contrast the in-person pathology elective, with some of the virtual resources that are available at this point and time?11:02 Are there any additional resources that you want to point out that are available now in 2021?12:34 Can you kind of dive in and provide advice for people that are following in your shoes who might be doing later electives this year or in the near future who are looking at applying to pathology in the next cycle?  13:41 Can you dive in and elaborate on what are some of the helpful things when students get onsite for one of these rotations?17:26 Can you help us understand how you go about cultivating those relationships? 19:36 Are there any kind of parting words of wisdom that you want to leave with future applicants that are checking out this podcast episode?20:47 Outro    

Perspectives from a visiting medical student: Path to success

Timestamps:00:00 Intro00:44 With this latest outbreak of the Delta variant with COVID-19, are laboratorians still working on new innovations for COVID?02:23 Could you go into more detail, elaborate for us about this COVID-19 innovation around sequencing? 04:25 Could you help us understand a little bit on what work is being done in those areas? 07:47 Could you help our audience understand what have these conversation been like now that we’re into this pandemic this far, and the way that laboratory medicine testing is moving? I imagine you’re having more conversations with some of your Infectious Disease colleagues and you’re having more conversations with public health these days?09:35 How do you answer that question?11:18 Are there one or two COVID-related challenges that have really been running around in your mind the past week?13:25 How is the Delta variant impacting what we’re thinking about for starting school?14:38 Outro Resources:American Academy of Pediatrics

COVID-19 laboratory innovations: Sequencing and diagnostics

Timestamps:00:00 Intro01:05 From your perspective, why is the blood inventory important to a hospital?04:17 What have you learned about managing a hospital’s blood inventory these past 18 months or so?08:09 I was wondering if you could give us a specific example on how are they trying to bridge that gap? 08:55 Can you explain who the Dream Team is?12:34 How does PVM look different on the hospital side? How is that being worked?16:33 How might physicians, non-pathologists, help their hospital’s blood inventory? What are the practical things that is within their sphere of control that they can help?20:52 What do you hope that our learners take away from these blood shortage challenges that we’re navigating right now?23:20 Outro 

Addressing the national blood shortage: Why blood inventory is so important

Timestamps:00:00 Intro02:15 Why is it not enough for learners just to focus on the curriculum of their program?04:30 What are two or three things that learners should pay attention to during their training?07:19 Paying attention to the habits of our mentors and understanding that those habits are what is reassuring them, that is a key source for their confidence in their clinical practice. What’s another thing?09:50 Do you have a third one that we should pay attention to?12:45 How could learners take ownership for their education and get that knowledge that’s inside their mentor’s heads, into their heads? Any strategies that you recommend?19:56 What are you thinking about explicitly incorporating into your training program with residents and fellows?25:05 Outro 

What should learners focus on during training?

Timestamps:00:00 Intro01:19 Could you help us understand, why should I consider getting an ethics consult? What value could this bring to my clinical practice?07:49 What should our audience understand in order to really work better with our local med ethics team?13:58 Could you help us understand about organizational ethics? How does that compare and contrast with that hospital ethics committee that you said everybody has and are most used to turning to?22:24 What would be your recommendation for how to reach out to who is doing organizational ethics at our institution?  25:00 I was wondering if you would be willing to share one or two predictions for the future of medical ethics to open our mind up to what are the main issues and questions, and how is your field evolving? 30:35 Outro 

Understanding medical ethics

Timestamps:00:00 Intro00:45 Why is it important to perform molecular testing on solid tumors?02:47 What is the significance of this testing for the patients and physicians?07:18 Can you share with us, what are some recent examples that have blown this door open about hereditary oncology?10:28 Can you talk a little bit about the challenge on how do we get the rapid rise in molecular knowledge and testing? What is your perspective?15:25 Can you elaborate a little bit on how you interact with your clinical colleagues on how to keep people up to date, or how to explore what’s the right thing to bring on to that test menu? 18:11 What’s your secret to leveraging those relationships?20:00 What does the future of molecular tumor testing look like?21:48 Outro 

Hereditary oncology: Molecular testing for solid tumors

Timestamps:00:00 Intro01:11 What are frozen sections, and why are they an important part of patient care?04:50 What are some of the challenges of actually performing a frozen section diagnosis?07:03 How has frozen section changed in recent years, or over the course of practice? Has it been practiced similarly over the years, and are there differences in frozen section practice in different hospitals?14:37 Given this uptick in the complexity of cases, how do you mentor people who are trying to find their way, i.e., the students and trainees?19:14 As a practicing Pathologist, where do you solicit your feedback from, and maybe an example of how you use that feedback to get better? 24:32 Looking at the future in pathology and surgical pathology, there’s so much interest in artificial intelligence and informatics; is that thought to play a role in the future of the frozen section practice?27:51 Outro 

Frozen sections: Value & challenges

Timestamps:00:00 Intro01:00 How does the cardiovascular laboratory support patient care?01:47 Can you tell us a bit about ceramides? What are they?04:14 When should ceramides be tested? 06:04 Can you modify someone’s ceramides such that the test can be repeated and monitored, or is it once in a lifetime because ceramides or more static?08:05 What is the controversary around ceramides? 09:52 Could you give our listeners an introduction to Lipoprotein(a)?11:45 Who should be tested for Lipoprotein(a)?13:59 How do we treat elevated Lipoprotein(a)? 17:20 How did your interests in laboratory medicine develop? How has this brought meaning for you in your career professionally? 19:23 Outro Resources:1.  Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification. Hilvo M, Vasile VC, Donato LJ, Hurme R, Laaksonen R. Front Endocrinol (Lausanne). 2020 Sep 29;11:570628. doi: 10.3389/fendo.2020.570628. eCollection 2020. PMID: 33133018 Free PMC article. Review. 2.  Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation. Fatica EM, Meeusen JW, Vasile VC, Jaffe AS, Donato LJ. Clin Biochem. 2020 Dec;86:45-51. doi: 10.1016/j.clinbiochem.2020.09.007. Epub 2020 Sep 28. PMID: 32997972 3.  Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors. Meeusen JW, Donato LJ, Kopecky SL, Vasile VC, Jaffe AS, Laaksonen R. Clin Chim Acta. 2020 Dec;511:138-142. doi: 10.1016/j.cca.2020.10.005. Epub 2020 Oct 12. PMID: 33058843 4.  Ceramide Scores Predict Cardiovascular Risk in the Community. Vasile VC, Meeusen JW, Medina Inojosa JR, Donato LJ, Scott CG, Hyun MS, Vinciguerra M, Rodeheffer RR, Lopez-Jimenez F, Jaffe AS. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1558-1569. doi: 10.1161/ATVBAHA.120.315530. Epub 2021 Feb 18. PMID: 33596665 5.  High-Sensitivity Cardiac Troponin for the Diagnosis of Patients with Acute Coronary Syndromes. Vasile VC, Jaffe AS. Curr Cardiol Rep. 2017 Aug 24;19(10):92. doi: 10.1007/s11886-017-0904-4. PMID: 28840515 Review. 6.  Natriuretic Peptides and Analytical Barriers. Vasile VC, Jaffe AS. Clin Chem. 2017 Jan;63(1):50-58. doi: 10.1373/clinchem.2016.254714. Epub 2016 Oct 10. PMID: 28062611 Review. 7.  Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. Jaffe AS, Vasile VC, Milone M, Saenger AK, Olson KN, Apple FS. J Am Coll Cardiol. 2011 Oct 18;58(17):1819-24. doi: 10.1016/j.jacc.2011.08.026. Epub 2011 Sep 29. PMID: 21962825 8.  Elevated cardiac troponin T levels in critically ill patients with sepsis. Vasile VC, Chai HS, Abdeldayem D, Afessa B, Jaffe AS. Am J Med. 2013 Dec;126(12):1114-21. doi: 10.1016/j.amjmed.2013.06.029. Epub 2013 Sep 28. PMID: 24083646 

Cardiovascular laboratory: Biomarkers, testing, & clinical implications

In this episode, Jeffrey (Jeff) Meeusen, Ph.D., assistant professor of Laboratory Medicine and Pathology and clinical chemist in the Division of Clinical Core Laboratory Services at Mayo Clinic, discusses the interface between subspecialties, as well as sustaining bridges between laboratory medicine and cardiology.

Sustainable bridges: Lab medicine & cardiology

In this episode, Reade Quinton, M.D., discusses what it takes to become a forensic pathologist, talks about common misconceptions related to the field, and describes what a day in the life of a forensic pathologist may include.

Forensic pathology 101

A Mayo Clinic curated podcast for physicians, laboratory professionals, and students; hosted by Dr. Justin Kreuter (the Bow Tie Bandit of Blood) and featuring trending topics from subject-matter experts.

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Lab Medicine Rounds

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