http://www.einstein.yu.edu - Jonathan Lai, Ph.D., and colleagues have engineered the first antibodies that can potentially neutralize the two deadliest strains of the virus that causes Ebola hemorrhagic fever. The findings were published online January 13 in the journal Scientific Reports. Dr. Lai, associate professor of biochemistry at Albert Einstein College of Medicine, and John Dye, Ph.D., branch chief of viral immunology at USAMRIID, were co-leaders on the study.

Science Talk

Science Talk: Antibody Neutralizes Two Deadliest Ebola Virus Species

http://www.einstein.yu.edu - New research on sickle cell disease by Paul Frenette, M.D., has found that using antibiotics to deplete the body’s microbiome may prevent acute sickle cell crisis and could offer the first effective strategy for warding off the disease’s long-term complications, such as organ failure. The findings were published online on September 16 in the journal Nature. Dr. Frenette is professor of medicine and of cell biology and chair and director of Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine.

Science Talk: Antibiotics May Thwart Sickle Cell Crisis

http://www.einstein.yu.edu - Results of a new survey of more than 1,000 U.S. adults has found that misperceptions about miscarriage and its causes are widespread. Results of the survey, conducted by Dr. Zev Williams show that guilt and shame are common and fewer than half of respondents say they received adequate emotional support from the medical community. The findings were published online on May 11 in the journal Obstetrics & Gynecology. Dr. Williams is director of the Program for Early and Recurrent Pregnancy Loss (PEARL) at Albert Einstein College of Medicine and Montefiore Health System and is assistant professor of obstetrics & gynecology and women’s health, and of genetics, at Einstein.

Science Talk: Survey Finds Miscarriage Widely Misunderstood

http://www.einstein.yu.edu - Kartik Chandran, Ph.D., explains the novel strategies he and his colleagues are using to develop treatments for Ebola viral infections. Watch 3-D animations showing how Ebola enters a cell and delivers its payload in order to replicate and spread throughout the body. Dr. Chandran is associate professor of microbiology & immunology at Einstein. Major funding for this research is provided by the NIH, U.S. Defense Threat Reduction Agency, Chan Family Foundation, and Albert Einstein College of Medicine.

Outsmarting Ebola Virus: Innovative Research on Treatment

http://www.einstein.yu.edu - With the help of animations, Betsy Herold, M.D. shows why some drugs that prevented HIV and herpes transmission in the lab failed to protect women in clinical trials. See how proteins in semen act as an “invisibility cloak” for HIV and herpes viruses allowing them to bypass drugs and infect cells. Using lab techniques informed by clinical results, Dr. Herold conducts translational research on the next generation of drugs to prevent HIV and HSV infection. She is professor of pediatrics and of microbiology and immunology at Albert Einstein College of Medicine and chief, division of pediatric infectious diseases at The Children’s Hospital at Montefiore.

Translational Research: Lab Vs. Real World HIV Prevention

http://www.einstein.yu.edu - A new study by Dr. Sophie Molholm suggests that measuring how fast the brain responds to sights and sounds could help in objectively classifying people on the autism spectrum and may help diagnose the condition earlier. The paper was published today in the online edition of the Journal of Autism and Developmental Disabilities. Dr. Molholm is associate professor in the Dominick P. Purpura Department of Neuroscience and the Muriel and Harold Block Faculty Scholar in Mental Illness in the department of pediatrics at Albert Einstein College of Medicine. Read full press release:http://dev.einstein.yu.edu/news/releases/1041/brainwave-test-could-improve-autism-diagnosis-and-classification/

Science Talk: Brainwave Test Could Improve Autism Diagnosis and Classification

http://www.einstein.yu.edu - Using animations and a walk through his lab, Dr. Steven Almo explains in lay terms why protein structure and shape are important in developing drugs to fight disease. See how proteins are turned into crystals, how X-ray crystallography works and how an immune cell’s ignition, accelerator and brakes can be manipulated to fight cancer or autoimmune disease. Dr. Almo is professor of biochemistry and Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology at Albert Einstein College of Medicine. Learn more about Dr. Almo's research at: www.einstein.yu.edu/faculty/almo

Why Protein Structure Matters in Drug Development: Lab Chat with Steven Almo, Ph.D.

https://www.einstein.yu.edu - Dr. Joe Verghese has found that nearly 1 in 10 met criteria for pre-dementia based on a simple test that measures how fast people walk and whether they have cognitive complaints. People who test positive for pre-dementia were twice as likely as others to develop dementia within 12 years. The paper was published online on July 16 in Neurology. Dr. Verghese is professor in the Saul R. Korey Department of Neurology and medicine at Einstein, chief of geriatrics at Einstein and Montefiore, and senior author of the Neurology paper.

Science Talk: Slow Walking Speed and Memory Complaints Can Predict Dementia

https://www.einstein.yu.edu - Determined to find a treatment for children with the degenerative brain disease Niemann-Pick Type C, Steven Walkley, D.V.M., Ph.D., turned a serendipitous laboratory discovery into a successful national research collaboration with other academic institutions and the National Center for Advancing Translational Sciences' program for rare diseases (Therapeutics for Rare and Neglected Diseases). These efforts led to an NIH Phase 1 clinical trial testing cyclodextrin as a therapy for children with this disease. Dr. Walkley is a professor in the Dominick P. Purpura Department of Neuroscience and director of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center at Albert Einstein College of Medicine.

Rare Diseases Research: Clinical Trial for Niemann-Pick Type C

https://www.einstein.yu.edu/cerc - Pediatrician Lisa Shulman shows the motor milestones expected in typically developing babies, from head control to walking and what pediatricians look for during a well-baby visit. She also explains the specific types of motor control a baby must master before the next milestone can be achieved. Dr. Shulman is associate professor of clinical pediatrics at Albert Einstein College of Medicine and an attending physician in pediatrics at The Children's Hospital at Montefiore. She is also director of the RELATE program for the diagnosis and treatment of autism and related disorders at Einstein's Children's Evaluation and Rehabilitation (CERC).

Baby Milestones: Motor Development

http://www.einstein.yu.edu - Researchers at Albert Einstein College of Medicine developed a mouse model in which molecules crucial to making memories (beta-actin mRNA) were given fluorescent "tags" so they could be tracked. This clip shows them traveling within a live brain cell in real time. Video Credit: Credit: Hye Yoon Park, Ph.D. Read news release: http://www.einstein.yu.edu/news/releases/968/watching-molecules-morph-into-memories/

mRNA in Motion

http:/www.einstein.yu.edu - The Western Diet -- defined by fried and sweet foods, processed and red meat, refined grains and high-fat dairy products -- has been liked to colon cancer. Leonard Augenlicht, Ph.D., explains his research into how diet impacts the colon and the development of the disease. Dr. Augenlicht is director of Einstein's Biology of Colon Cancer Program and a professor of medicine and of cell biology at Albert Einstein College of Medicine.

The Western Diet and Colon Cancer: Lab Chat with Leonard Augenlicht, Ph.D.

http://www.einstein.yu.edu - Dr. Hannes Buelow has identified a gene that orchestrates the crucially important branching of nerve fibers that occurs during development. The findings were published online today in the journal Cell. Dr. Buelow is associate professor in the Dominick P. Purpura Department of Neuroscience and of genetics at Albert Einstein College of Medicine. See accompanying release: http://www.einstein.yu.edu/news/releases/941/previously-unstudied-gene-is-essential-for-normal-nerve-development/

Science Talk: Previously Unstudied Gene Is Essential for Normal Nerve Development

http://www.einstein.yu.edu - Dr. Jean Hébert has found that inner-ear dysfunction can directly cause neurological changes that increase hyperactivity. The paper was published online in the journal Science on September 5, 2013. Dr. Hébert is professor in the Dominick P. Purpura Department of Neuroscience and of genetics at Albert Einstein College of Medicine. See accompanying release: http://www.einstein.yu.edu/news/releases/932/inner-ear-disorders-may-cause-hyperactivity/

Science Talk: Inner-Ear Disorders May Cause Hyperactivity

http://www.einstein.yu.edu - John Foxe, Ph.D. shows how his lab measures multisensory integration in high-functioning children with autism spectrum disorder (ASD). He found that younger children with ASD have trouble integrating the auditory and visual cues while listening to speech, but that the problem clears up in adolescence. Dr. Foxe is director of research at Albert Einstein College of Medicine's Children's Evaluation and Rehabilitation Center and professor of pediatrics and of neuroscience. Watch video about the study: http://youtu.be/iES0xGDqbQc See the press release: http://www.einstein.yu.edu/news/releases/931/autistic-children-can-outgrow-difficulty-understanding-visual-cues-and-sounds/

Multisensory Integration: Testing Children With Autism

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