We look at 5 recent publications in the field of toxicology.Costa, C. et al. Distinguishing between contact and administration of heroin from a single fingerprint using high resolution mass spectrometry. (2020) Journal of Analytical Toxicology. 44: 218-225Kaufmann, A. et al. Partially overlapping sequential window acquisition of all theoretical mass spectra: A methodology to improve the spectra quality of veterinary drugs present at low concentrations in highly complex biological matrices. (2020) Rapid Communications in Mass Spectrometry. 34: e8638Kraemer, M. et al. Detectability of various cannabinoids in plasma samples of cannabis users: Indicators of recent cannabis use? (2019) Drug Testing and Analysis. 11:1498-1506Margalho, C. et al. Determination of new psychoactive substances in whole blood using microwave fast derivatization and gas chromatography/mass spectrometry. (2020) Journal of Analytical Toxicology. 44:92-102Gundersen, P. et al. Retrospective screening of synthetic cannabinoids, synthetic opioids and designer benzodiazepines in data files from forensic post mortem samples analysed by UHPLC-QTOF-MS from 2014 to 2018. (2020) Forensic Science International. 311: 1-11Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

The Toxpod

5 in 30 (Fingerprints, SWATH and retrospective screening)

Tim chats with Alberto Salomone about workplace testing, hair analysis, and new psychoactive substances. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

Workplace testing with Alberto Salomone

Peter chats with Richard Bade about the advantages and challenges of wastewater analysis.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

Drugs in wastewater with Richard Bade

Tim chats with Michelle Peace about her current research on vaping, and her experiences in the field of forensic toxicology.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

Vaping with Michelle Peace

We channel our sports withdrawal into a toxicology related draft.Thanks to Michaela Kenneally and Stephen Trobbiani for participating in this episode.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

Drafting an analytical method

The California Association of Toxicologists Spring meeting has been postponed due to COVID restrictions, but that won't stop us from chatting with some of the planned speakers! Thanks to Luke Rodda, Jarrad Wagner, Juliet Kinyua and Alan Wu for participating in this episode.Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

CAT conference 2020

We talk about synthetic cannabinoids (or is that SCRAs?) with medicinal chemist Samuel Banister. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

Synthetic Cannabinoids (with Samuel Banister)

We look at 5 recent publications in the field of toxicology.Blanckaert, P. et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. (2020) Drug Testing and Analysis. 12: 422-430Reinstadler, V. et al. A validated workflow for drug detection in oral fluid by non-targeted liquid chromatography-tandem mass spectrometry. (2019) Analytical and Bioanalytical Chemistry. 411:867-876Benaglia, L. et al. Testing wastewater from a music festival in Switzerland to assess illicit drug use. (2020) Forensic Science International. 309:1-8Munoz-Munoz, A. et al. Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method. (2020) Journal of Analytical Toxicology. 44:36-40Darke, S. et al. Characteristics and circumstances of death related to gamma hydroxybutyrate (GHB). (2020) Clinical Toxicology. Published online 18 Feb 2020. Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

5 in 30 (Isotonitazene, wastewater and MS interferences)

Season 3 drops on April 29. Subscribe now!

Season 3 preview

In our last episode of the season, we look at 5 recent publications in the field of toxicology.Steuer, A. et al. Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans. (2019) Drug Testing and Analysis. 11 (6):813-823Souza, R. et al. Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil. (2019) Journal of Chromatography B. 1124: 197-203 Snamina, M. et al. Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs. (2019) Talanta. 204:607-612Fabresse, N. et al. Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances. (2019) Drug Testing and Analysis. 11 (5):697-708Sitasuwan, P. et al. Comparison of purified beta-glucuronidases in patient urine samples indicates a lack of correlation between enzyme activity and drugs of abuse metabolite hydrolysis efficiencies leading to potential false negatives.(2019) Journal of Analytical Toxicology. 43 (3):221-227Contact us at thetoxpod@sa.gov.auThe Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer.

5 in 30 (Ayahuasca, metabolomics and bone marrow)

In this episode, we dive into the techniques, practices, and guidelines used in forensic toxicology for drug identification. Do we have the balance right?Some of the available identification guidelines:World Anti-Doping Agency (WADA)European Workplace Drug Testing Society (EWDTS)Organisation of Scientific Area Committees (OSAC)Gesellschaft für Toxikologische und Forensische Chemie (GTFCh)That article Pete mentioned on amphetamine isomers:Brown, D. H., et al. (2016). "Beta-methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation." Drug Test Anal 8(3-4): 344-350.Contact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 

When is a Drug Not a Drug?

During his recent trip to the TIAFT2019 conference in Birmingham, England, Peter caught up with a few toxicologists to discuss some of their recent work.Barry Logan's group has published their findings on kratomJoin the HighResNPS communityLearn more about The International Association of Forensic Toxicologists at www.tiaft.orgContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 

On the Spot at TIAFT2019

Peter is joined by toxicologists Sarah Wille (Belgium) and Luke Rodda (USA) to discuss how the field of toxicology is changing and where it will lead us. Recorded live at TIAFT2019 in Birmingham, England.Learn more about The International Association of Forensic Toxicologists at www.tiaft.orgContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 

Toxicology in the 21st Century (live at TIAFT2019)

The world of scientific publishing is a mysterious place - even to many who publish regularly! How does reviewing work? What are predatory journals? Why should scientists write?We are joined by Professor Roger Byard (forensic pathologist, prolific writer, and editor-in-chief of Forensic Science, Medicine and Pathology) as we peek behind the curtain of the publishing world. Roger's editorial - The forensic implications of predatory publishingABC Radio podcast on predatory publishingContact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 

Publish or Perish (or both!)

We are joined by Dimitri Gerostamoulos, Head of Forensic Science and Chief Toxicologist at the Victorian Institute of Forensic Medicine. Contact us at thetoxpod@sa.gov.au The Toxpod is a production of Forensic Science SA and the South Australian Attorney General's Department. The opinions expressed by the hosts are their own and do not necessarily reflect the views of their employer. 

Dimitri Gerostamoulos

Forensic Toxicology: It's a matter of half-life and death

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The Toxpod

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