For thousands of years, there have been four basic tastes recognized across cultures. But thanks to Kumiko Ninomiya (a.k.a. the Umami Mama), scientists finally accepted a fifth. Could there be even more? (First published in 2022.) Guests: Kumiko Ninomiya, biochemist and former director of the Umami Information Center; Gary Beauchamp, former director of the Monell Chemical Senses Center; Sarah Tracy, historian of science; Camilla Arndal Andersen, neuroscientist; Paul Breslin, professor at Rutgers University For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Unexplainable

How umami blew up taste

Some of the largest lakes in the world have been buried under miles of ice for millions of years. Is there life hiding down there? And if so, could life be found in even more extreme places … beyond our planet? Guest: John Priscu, microbiologist at Montana State University For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

What’s hiding under the Antarctic ice?

Genetic libraries are treasure troves of information about life from around the world. They’re helping researchers develop everything from vaccines to crops to cosmetics. But who actually benefits from the discoveries scientists make using all this DNA and RNA? Guests: Benji Jones, environmental correspondent at Vox’s Future Perfect; Deborah Fuller, professor of microbiology at the University of Washington For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Biopiracy

Some scientists think an explosion of AI awareness and feeling might be just around the corner. Others think it’s impossible for an AI to ever become conscious. How will we know? Guest: Oshan Jarow, staff writer at Vox’s Future Perfect For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Will AI ever ... feel?

It’s that time of year again. If you’re changing things up, there’s a lot of diets out there that claim to help you live longer. Our friends at Today, Explained ask: How much of this is real and how much of it is nonsense? Guests: Anahad O’Connor, health columnist at the Washington Post; Saul Justin Newman, researcher at the University College London Centre for Longitudinal Studies For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

New year, new diet, live forever?

The wildest stories that never made it into our episodes. Until now. Guests: Amy Boddy, anthropological scientist at the University of California, Santa Barbara; Jayme Locke, transplant surgeon at the University of Alabama at Birmingham; Jonathan Jiang, research scientist at the Jet Propulsion Laboratory For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Mysteries we can’t stop thinking about

Dogs were the first domesticated animal in history, emerging from wolves some 20,000 years ago. But how did wolves become dogs? To find the answer, scientists have to play with a lot of puppies. (First published in 2023.) Guest: Kathryn Lord, evolutionary biology researcher at UMass Chan Medical School For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Who let the wolves in?

We know Neanderthals and early modern humans coupled up. But when did they meet, exactly? And where? Some fossilized smoke and a baby tooth might hold clues. Guest: Adam Cole of HowTown For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Where to meet a Neanderthal

It’s not great to be a lab rat. And it turns out, lab rats might not be that great for science either. Could the future be little lab-grown brain clumps? Guests: Rachel Nuwer, science journalist; Lisa Genzel, professor of neuroscience at Radboud University This episode has been updated. An earlier version didn’t differentiate between two stages of drug development. For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Pinky and the (lab-grown) Brain

This week on Unexplainable or Not, we’ve got three scientific mysteries all about left and right. Jonquilyn Hill, host of Vox’s new podcast Explain It to Me, is going to guess which of them has been solved and which ones are still unexplainable. Guest: S. Furkan Ozturk, researcher at Harvard University For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Why are there lefties and righties?

For decades, scientists thought that placebos only worked if patients didn’t know they were taking them. Not anymore: You can give patients placebos, tell them they’re on sugar pills, and they still might feel better. No one is sure how this works, but it raises a question: Should doctors embrace placebos in mainstream medicine? (First published in 2021.) Guests: Ted Kaptchuk, professor at Harvard Medical School; Darwin Guevarra, professor of psychology at Miami University; Luana Colloca, professor at the University of Maryland School of Nursing For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Placebos work. Why?

It makes sense that we run away from scary things. That’s a good way to stay alive. But why do some people also love scary things? Why do people gravitate toward horror? Guests: Mathias Clasen and Marc Andersen, co-directors of the Recreational Fear Lab at Aarhus University For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Why is horror so fun?

Drugs like ecstasy and mushrooms have shown promise as mental health treatments, but they’re also exposing some major cracks in how scientists study the brain. Guests: Jonathan Lambert, science journalist; Boris Heifets, professor at Stanford University of Medicine; Amy Mcguire, professor at Baylor College of Medicine For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Are psychedelics breaking science?

How we feel emotionally may be influenced by unseen troves of microbial life that live inside us. Is it possible to harness this gut power? (First published in 2022) Guests: Michael Gershon, professor of pathology at Columbia University; and Katerina Johnson, microbiome researcher at Oxford University For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Your gut’s feelings

As the world gets warmer and storms get worse, insurance companies are jacking up rates — or refusing to cover homeowners altogether. Is the future uninsurable? Guests: Umair Irfan, correspondent at Vox; Karen Clark, co-founder and CEO of Karen Clark & Company; Joe Skuba, VP at The Gray Insurance Company; and Carolyn Kousky, Associate VP at Environmental Defense Fund For show transcripts, go to vox.com/unxtranscripts For more, go to vox.com/unexplainable And please email us! unexplainable@vox.com We read every email. Support Unexplainable by becoming a Vox Member today: vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

Is insurance doomed?

Unexplainable takes listeners right up to the edge of what we know … and then keeps on going. Host Noam Hassenfeld and an all-star team of reporters — Byrd Pinkerton, Meradith Hoddinott, and Mandy Nguyen — tackle scientific mysteries, unanswered questions, and everything we learn by diving into the unknown. New episodes drop every Wednesday.

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Unexplainable

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