UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements LINE1 retrotransposons between species. University of Southern California professor Joseph Hacia discusses studies profiling phytanic acid levels in red blood cells obtained from humans and captive non-human primates all on low phytanic acid diets. Emory University professor James Rilling discusses the difference of arcuate fasciculus between human and non-human primate brains and how the specialization of speech has helped humans evolve. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37527]

CARTA - Center for Academic Research and Training in Anthropogeny (Audio)

CARTA: Comparative Anthropogeny: From Molecules to Societies - Carol Marchetto Joseph Hacia and James Rilling

This symposium addresses several important distinctly human characteristics that range from molecules, to metabolism, anatomy, disease, and behavior. Goals include transdisciplinary interactions, improved self-understanding, promotion of ethically sound studies to explain known differences, and the generation of new, potentially unexplored, insights on uniquely-human specializations. Given the interest in understanding our evolution, this symposium will also help to organize how and in what sequence distinctly human physical, mental, social, and cultural features evolved. Such understanding may help explain the origin of our species and how it came to now directly shape the planet, giving rise to the Anthropocene (a proposed geological epoch distinguished by human influence on climate and the environment). Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37534]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Questions Answers and Closing Remarks

Unlike our closest primate relatives, chimpanzees and bonobos, humans form strong intergroup ties which can mitigate coalitionary aggression and make peace possible. However, such bonds can also be used to build larger alliances that take such conflicts to a new level of magnitude, supported by cultural and linguistic proficiencies. Arizona State University and University of Utah professor Polly Wiessner addresses intergroup ties between humans, chimpanzees and bonobos, explores some of the possible evolutionary developments that contributed to the human disposition to form mutually supportive external bonds, and then discusses the impact of social ties on coalitionary action. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37383]

CARTA: Comparative Anthropogeny: From Molecules to Societies - The Impact of Intergroup Social Ties on Coalitionary Aggression - Polly Wiessner

Identifying cellular and molecular differences between human and non-human primates is essential to the basic understanding of the evolution and diversity of our own species. While preserved tissues are the main source of comparative studies between humans, chimpanzees and bonboos, the samples do not accurately represent the traits of live cell behavior and cannot be genetically manipulated. UC San Diego professor Carol Marchetto discusses how a comparative gene expression analysis of human and non-human primates revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37377]

CARTA: Comparative Anthropogeny: From Molecules to Societies - LINE1 Retrotransposons - Carol Marchetto

Emory University professor Dietrich Stout discusses an evolutionarily motivated definition of technology that highlights three key features: material production, social collaboration, and cultural reproduction; UC San Diego professor Pascal Gagneux discusses how recent comparative genome studies have revealed that this polymorphic system is ancient and shared between humans and non-human primates, this despite the fact that none of the great ape species carries all four ABO blood types; and University of Utah professor James O’Connell discusses food sharing, evaluates one hypothesis that focuses on males acquiring big game meat and marrow to provide for mates and offspring. The other hypothesis surrounds how certain kinds of savanna plant food set up the forager interdependence which propelled all aspects of life history change. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37528]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Dietrich Stout Pascal Gagneux and James O'Connell

Arizona State University and University of Utah professor Polly Wiessner addresses intergroup ties between humans, chimpanzees and bonobos and explores some of the possible evolutionary developments that contributed to the human disposition to form mutually supportive external bonds, and then discusses the impact of social ties on coalitionary action; UC San Diego professor Rafael Nuñez discusses the comparative analysis of “quantity” and “number”, and the implications it has for debates about the origins of other human special capacities such as geometry, music, and art; and UC San Diego School of Medicine professor Nissi Varki discusses the incidence of carcinomas, including the rarity of occurrence of common human carcinomas in captive chimpanzees. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37529]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Polly Wiessner Rafael Núñez and Nissi Varki

This symposium addresses several important distinctly human characteristics that range from molecules, to metabolism, anatomy, disease, and behavior. Goals include transdisciplinary interactions, improved self-understanding, promotion of ethically sound studies to explain known differences, and the generation of new, potentially unexplored, insights on uniquely-human specializations. Given the interest in understanding our evolution, this symposium will also help to organize how and in what sequence distinctly human physical, mental, social, and cultural features evolved. Such understanding may help explain the origin of our species and how it came to now directly shape the planet, giving rise to the Anthropocene (a proposed geological epoch distinguished by human influence on climate and the environment). Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37447]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Welcome and Opening Remarks

Technology is clearly central to human life and evolution but remains hard to define and study. Emory University professor Dietrich Stout discusses an evolutionarily motivated definition of technology that highlights three key features: material production, social collaboration, and cultural reproduction. This perspective has important implications for the way we conceptualize and study the origins and evolution of human technologies. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37385]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Technology - Dietrich Stout

Humans and many other species have biologically endowed abilities for discriminating “quantities” to some degree (e.g., subitizing), but only humans, via the distinct capacity of “symbolic reference” exhibit “number” — i.e., exact symbolic quantification. Language, with its symbolic properties although present in all human cultures, is a necessary condition for “number” but it is not a sufficient condition for it. UC San Diego professor Rafael Nuñez discusses the comparative analysis of “quantity” and “number”, and the implications it has for debates about the origins of other human special capacities such as geometry, music, and art. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37386]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Quantity and Number - Rafael Nuñez

Sialic acid-recognizing immunoglobulin-type lectins (Siglecs) are a family of cell surface proteins prominently expressed on immune cells in mammals. Siglec-11 is an example of an inhibitory Siglec. It was the first protein in the brain found to be “human-specific”: non-human primates express Siglec-11 in other tissues but not in the central nervous system. UC San Diego School of Medicine professor Ajit Varki discusses the importance of Siglec-11 and the paired receptor Siglec-16, and how they play significant roles in regulating inflammation, and have several uniquely human features including expression in brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37380]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Siglec-11 Expression in the Brain - Ajit Varki

Language is a human cognitive specialization, and as such, is expected to be supported by human neurological specializations. The arcuate fasciculus is a white matter fiber tract that connects Wernicke’s and Broca’s language areas in the human brain, and also connects the homologues of Wernicke’s and Broca’s areas in non-human primate brains. Emory University professor James Rilling discusses the difference of arcuate fasciculus between human and non-human primate brains and how the specialization of speech has helped humans evolve. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37381]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Human Arcuate Fasciculus - James Rilling

During embryogenesis, the three germ layers (endoderm, ectoderm, mesoderm) differentiate into epithelial and non-epithelial cells, which eventually form differentiated tissues and organs. Abundant data now indicates that we humans are very closely related to other hominids including chimpanzees, bonobos, gorillas, and orangutans, the so-called "great apes". UC San Diego School of Medicine professor Nissi Varki discusses the incidence of carcinomas, including the rarity of occurrence of common human carcinomas in captive chimpanzees. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37382]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Incidence of Carcinomas - Nissi Varki

Diet has played a major role in the evolution of human and non-human primate digestive systems. Phytanic acid is a potentially toxic branched chain fatty acid that can be acquired in humans by ingesting plant and/or animal products. Although it was established that humans cannot derive phytanic acid from chlorophyll and instead normally obtain it only from meat, dairy, and fish products, less was known about the capacity of non-human primates with proportionally larger hindguts to obtain phytanic acid from plant materials. University of Southern California professor Joseph Hacia discusses studies profiling phytanic acid levels in red blood cells obtained from humans and captive non-human primates all on low phytanic acid diets. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37379]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Phytanic Acid Metabolism - Joseph Hacia

ABO Blood groups represent the first described human molecular polymorphism. The ABO gene encodes variants of a protein (a glycosyltransferase) that produces the short sugar chains on glycoproteins and glycolipids that define the A, B, or O antigens. These antigens are found on red blood cells, plasma glycoproteins, and other cell types in various tissues. Individual humans can have one of four blood types based on the two alleles inherited from both parents at the ABO locus: blood type A, B, AB, or O. UC San Diego professor Pascal Gagneux discusses how recent comparative genome studies have revealed that this polymorphic system is ancient and shared between humans and non-human primates, this despite the fact that none of the great ape species carries all four ABO blood types. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37378]

CARTA: Comparative Anthropogeny: From Molecules to Societies - ABO Blood Groups - Pascal Gagneux

Humans are unusual in that we depend on shared foods, especially among families and friends and between potential mates. Food sharing occurs between healthy individuals and those that are infirm or elderly. We also differ from other great apes in our early ages at weaning, late ages at maturity, short birth intervals and survivorship decades past menopause. The emergence of these patterns was crucial to early human development. In light of observations among modern East African hunter-gatherers, University of Utah professor James O’Connell evaluates two alternatives. He discusses one hypothesis that focuses on males acquiring big game meat and marrow to provide for mates and offspring. The other hypothesis surrounds how certain kinds of savanna plant food set up the forager interdependence which propelled all aspects of life history change. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37384]

CARTA: Comparative Anthropogeny: From Molecules to Societies - Food Sharing - James O'Connell

Multidisciplinary researchers explore the origins of humanity and the many facets of what makes us human.

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