Dan Kaufman, MD, PhD, David Traver, PhD, Gene Yeo, PhD, MBA, discuss the impact of genomics in relation to stell cell research including potential therapeutics for MDS and the role if the somite in hematopoietic stem cell fate. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37561]

Genetics (Audio)

Genomics - Sanford Stem Cell Symposium

There are at least 2500 proteins that bind RNA. Gene Yeo, PhD, MBA, explains how his lab studies these RNA binding proteins and their impact on human health Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37589]

RNA Binding Proteins: A Splicing Story in IPSC Models of MDS with Gene Yeo - Sanford Stem Cell Symposium

Jonathan Sebat, PhD shares current research on how combinations of rare gene mutations and complex common variant risk factors contribute to autism. Series: "Autism Awareness Programs" [Health and Medicine] [Science] [Show ID: 37658]

Genetics of Autism with Jonathan Sebat PhD

To Sheng-Ying Pao, the power of reframing CRISPR lies in what is absolutely ordinary: paper. In CRISPaper, Pao revisited a cultural past in the ancient art of papermaking. In ancient China, wild rice was used to make paper. Pao took rice stalks from plants edited with CRISPR and ground the fibers into pulp. She then poured the pulp over a mesh screen. Every time she dipped the screen into water, the plant fibers would lift and resettle on top of the mesh, eventually making paper. Through the genome-edited rice plant, an ancient practice was juxtaposed with cutting-edge technology. Series: "UC Berkeley News" [Science] [Arts and Music] [Show ID: 37388]

CRISPaper: Understanding CRISPR Gene-Editing through Art

UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

UCSF Berkeley UCLA to Launch Sickle Cell Trial Using CRISPR

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Herman Pontzer explores the evolution of metabolism, Grazyna Jasienska discusses different effects of activity on women's reproductive health and Ellen Breen explores an evolutionary pathway for high endurance activity. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 37187]

CARTA: The Evolution of Human Physical Activity - Herman Pontzer Grazyna Jasienska Ellen Breen

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Jandy Hanna explores climbing in human evolution. Most primates live and move in the trees, but humans have evolved to move bipedally on the ground. Primates’ arboreal life-style has long been thought to have allowed the evolution of human beings’ unusual form of movement. We know much about how horizontal movement on branches differs in primates relative to most other mammals. But only recently have we begun to learn about how climbing is accomplished by non-human primates, and how such movement may have permitted early human ancestors to move upright. Key findings regarding the biomechanics of climbing, and what these data may mean for understanding human movement and exercise, are discussed. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36948]

CARTA: The Evolution of Human Physical Activity - Jandy Hanna -The Rise and Fall of Climbing in Human Evolution

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Herman Pontzer explores the evolution of human metabolism and its role in our evolution and health. From an evolutionary perspective, life is a game of turning energy into offspring. The strategies that species use to acquire energy, in the form of food, and allocate energy to the essential tasks of growth, maintenance, movement, and reproduction, are incredibly diverse and reflect the ecological pressures and opportunities encountered. There is a deep evolutionary history of the human metabolic strategy and our divergence from other apes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36951]

CARTA: The Evolution of Human Physical Activity - Herman Pontzer - The Evolution of Human Metabolism  

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Ellen Breen explores an evolutionary pathway for high endurance activity. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36945]

CARTA: The Evolution of Human Physical Activity - Ellen Breen - A Human Genetic Mechanism for Endurance Running

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Yana Kamberov explores how sweating evolved and what it means for Homo sapiens. Humans use sweating as the primary mechanism to dump body heat. Humans’ ability to effectively harness sweating as a thermoregulatory mechanism is a product of the evolution of a massively increased sweat gland density and a drastic reduction in the size of body hair. Advances have been made in identifying the genetic basis for how these unique and essential adaptations of human physiology evolved. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36949]

CARTA: The Evolution of Human Physical Activity - Yana Kamberov - Genetic Drivers of Human Thermoregulatory Skin Traits

Explores cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]

CARTA: Cellular and Molecular Explorations of Anthropogeny - Wysocka: Making Faces: Regulatory Evolution and Variation in the Human Neural Crest

Human physical activities differ significantly from other species. How, when and why did these capabilities evolve? What adaptations underlie them? And how did the evolution of human physical activity affect other key human characteristics that have advanced our species? Tatum Simonson explains adaptations to altitude and diving. Humans have persisted for hundreds of generations under challenging environmental extremes. Adaptations to such environments have been essential for survival, enabling populations to trek successfully among high mountain tops or to dive deeply into vast seas. Unique genetic signatures, resulting from thousands of years of strong selective pressures in these environments, have been discovered within the DNA of present-day populations. These findings provide important clues into evolutionary processes in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 36946]

CARTA: The Evolution of Human Physical Activity - Tatum Simonson - Human Adaptation to High Altitudes and Aquatic Environments

Breakthroughs in genomics and targeted therapies are revolutionizing the practice of clinical oncology. Precision genomics and immunotherapy offer promise to improve outcomes in cancer, but doing so means we need to move beyond historical models for cancer diagnosis and treatment. Razelle Kurzrock, MD discusses insights from this rapidly changing field and addresses some of the ethical challenges that must be met if we are to transform the lives of patients with cancer. Series: "Exploring Ethics" [Health and Medicine] [Show ID: 36637]

Precision Genomics and Immunotherapy: Cancer and Beyond - Exploring Ethics

Mark Tuszynski, MD, Ph.D., Bob Yant, and Lawrence S.B. Goldstein, Ph.D. discuss the newest research and treatments for spinal cord injury, including how neural stem cells may be leveraged to potentially regain function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37102]

A Closer Look at...Spinal Cord Injury

Experts address altered states of the mind that are deliberately induced by humans. We will address what is known about origins and mechanisms of these mind-altering practices. In doing so, we hope to gain new insights into the origins and workings of the human mind. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 36671]

CARTA: Altered States of the Human Mind: Implications for Anthropogeny: Kenneth Kidd - Alcohol Metabolism and Alcoholism

University of California faculty present the latest findings in genetic research and discoveries.

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Genetics (Audio)

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