TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Lupus autoantibodies bind GluN2A-containing NMDA receptors (Nat Commun) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

This Week in Neuroscience

TWiN 22: It's never lupus

TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Listener poll - please take it Striatal dopamine and hallucination in mice (Science) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 21: How do we know if a mouse is hallucinating?

While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Representational drift in olfactory cortex (Nature) (open preprint) Ed Yong on representational drift (Atlantic) Letters read on TWiN 20 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 20: Drifting aromas in the brain

On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 19: Glia 101

Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Mauro’s work on TWiM 131 and 193 Separating genetics and microbiome in autism (Cell) Please take our listener poll Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli

Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Michael Nitabach Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode C. elegans discriminates colors (Science) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 17: Worms see the light with Michael Nitabach

Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators. Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung Guest: Stefano Brigidi Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Genomic decoding of neuronal depolarization (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 16: Neuronal depolarization with Stefano Brigidi

Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Maternal microbiome influences fetal neurodevelopment (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv 

TWiN 15: Microbiome and neurodevelopment with Helen Vuong

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Reducing Alzheimer-like pathology in mice (Nat Neurosci) Letters read on TWiN 13 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 14: Reducing Alzheimer-like pathology in mice

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Transcriptional programs associated with long-term memory (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 13: mRNAs for long-term memory

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd   Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Thalamic orphan receptor in short term memory (Cell) Anosmia in SARS-CoV-2 infected mice (Nature) Letters read on TWiN 12 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 12: A gene for short-term memory

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Single-cell transcriptomics of reptile cortex (Science) Innovations in primate interneurons (Nature) Human versus mouse cortex (Nature) Letters read on TWiN 11 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 11: A dollar per neuron

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode IL-33 promotes synaptic plasticity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 10: Remodeling synapses with a cytokine

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Preparing a neurology department for COVID-19 (Neurology) Managing comatose COVID-19 patients (Ann Neurol) Neuropathology of COVID-19 (NEJM) Letters read on TWiN 9 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 9: COVID-19 neurology with Genna Waldman

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Converting glia to neurons (Cell) Reversing Parkinson's disease (Nature) Letters read on TWiN 8 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 8: Replacing lost neurons

This Week in Neuroscience is a podcast about the nervous system.

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This Week in Neuroscience

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