Featuring articles on LentiGlobin for sickle cell disease, tisagenlecleucel in aggressive B-cell lymphoma, axi-cel for relapsed or refractory large B-cell lymphoma, and EDP-938 to treat respiratory syncytial virus; a review article on electroconvulsive therapy; a case report of a woman with rapidly progressive weakness in the right arm and recurrent falls; and Perspective articles on health care safety during the pandemic and beyond, on inherited patients taking opioids for chronic pain, and on home help. 

NEJM This Week — Audio Summaries

NEJM This Week — February 17, 2022

Featuring articles on molnupiravir for outpatient treatment of Covid-19, cemented or uncemented hemiarthroplasty for hip fracture, efficacy of the NVX-CoV2373 vaccine against Covid-19, PD-1 inhibition in relapsed cervical cancer, pembrolizumab for triple-negative breast cancer, and a pernicious cycle affecting premalignant stem cells; a review article on marginal-zone lymphomas; a case report of a man with bilateral hearing loss and eye redness; and Perspective articles on racial biology and medical misconceptions, on developing new models for health, and on roulette. 

NEJM This Week — February 10, 2022

Featuring articles on gene therapy for β-thalassemia, mosquito nets and survival to adulthood in Tanzania, lenvatinib plus pembrolizumab for advanced endometrial cancer, and immune checkpoint therapy in esophageal cancer; a review article on fever of unknown origin; a Clinical Problem-Solving on the calm before the storm; and Perspective articles on using economics to inform public health policy, on automatic insurance policies, and on the care that was needed. 

NEJM This Week — February 3, 2022

Featuring articles on remdesivir for prevention of Covid-19 progression, cardiovascular and cancer risk with tofacitinib, tricuspid repair in mitral-valve surgery, duration of Covid-19 vaccine protection in the U.K., polatuzumab vedotin in diffuse large B-cell lymphoma, and anti-idiotype antibodies in SARS-CoV-2; a review article on medical conditions and high-altitude travel; a case report of a boy with fever, joint pain, and abdominal cramping; and Perspective articles on universal coronavirus vaccines, on transparency and the doctor–patient relationship, and on “Please don’t keep me”. 

NEJM This Week — January 27, 2022

Featuring articles on a randomized closed-loop trial in very young children with diabetes, microbiome therapy for C. difficile infection, secondary prophylaxis for latent rheumatic heart disease, targeting mutant HER2 in non–small-cell lung cancer, urinary sodium and potassium and cardiovascular risk, and on aesthetic distance and empathy; a review article on rapid diagnostic testing for SARS-CoV-2; a case report of a man with a recurrent left pleural effusion; and Perspective articles on research participation and diversity. 

NEJM This Week — January 20, 2022

A 38-year-old woman with type 2 diabetes has a telemedicine visit after learning that a person with whom she had close contact at an indoor wedding 3 days earlier has tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The woman reports that she is asymptomatic and received a second vaccination against SARS-CoV-2 approximately 9 months ago but has not received a booster vaccination. She attended the wedding with her husband, who has also received two vaccinations, and her two unvaccinated children, who are 5 and 8 years of age. Her husband had mild nasal congestion and a cough the evening before her appointment. She had previously purchased rapid diagnostic tests that received emergency use authorization from the Food and Drug Administration for home-based SARS-CoV-2 testing and wonders whether using these tests would be appropriate. What would you advise? Full-text recordings of Clinical Practice articles may be found at NEJM.org. 

Rapid Diagnostic Testing for SARS-CoV-2 by P.K. Drain

Featuring articles on the efficacy of mRNA vaccines in U.S. veterans, Covid-19 vaccine effectiveness in New York state, FFR-guided PCI as compared with coronary bypass surgery, an acute myeloid leukemia case after gene therapy for sickle cell disease, cannabis legalization and THC levels in injured drivers, oocytes from stem cells, and a new journal in the NEJM Group family; a review article on biologic therapies for severe asthma; a case report of a man with motor neuron disease and odd behaviors during sleep; and Perspective articles on reengineering GME in a pandemic and on expanded lung and colorectal cancer screening. 

NEJM This Week — January 13, 2022

Featuring articles on eltrombopag in severe aplastic anemia, nivolumab plus LAG-3 blockade in melanoma, the BNT162b2 vaccine against Covid-19 in 5-to-11-year-olds, azithromycin for yaws eradication, and abortion outcomes with unrestricted mifepristone; a review article on snake envenomation; a Clinical Problem-Solving on being confused about confusion; and Perspective articles on the patchwork U.S. public health system, on obstacles to physicians’ emotional health, and on the doctor’s oldest tool. 

NEJM This Week — January 6, 2022

Featuring articles on chlorthalidone for hypertension in advanced chronic kidney disease, ticagrelor versus clopidogrel in stroke or transient ischemic attack, dolutegravir in children with HIV-1 infection, angiography after out-of-hospital cardiac arrest, and the 2021 Nobel Prize in Chemistry; a review article on the determination of brain death; a case report of a boy with transient weakness, facial droop, and slurred speech; and Perspective articles on whether we should include race or ethnicity at the beginning of clinical case presentations, on calling out aversive racism in academic medicine, on closing the gender pay gap in medicine, and on trust, faith, and Covid. 

NEJM This Week — December 30, 2021

Featuring articles on the effects of a Covid-19 vaccine booster, spesolimab for generalized pustular psoriasis, decentralized molecular testing for tuberculosis, and consultative medicine; a review article on immune and genome engineering as the future of transplantable tissue; a case report of a woman with respiratory failure and altered mental status; and Perspective articles on clinical care and Amazon, on Covid-19 vaccination in American Indians and Alaska Natives, on tobacco-free nicotine, and on a divisive ruling on devices. 

NEJM This Week — December 23, 2021

Featuring articles on daprodustat in patients undergoing dialysis and in those not undergoing dialysis, chemotherapy in node-positive breast cancer, a phase 3 trial of the ChAdOx1 nCoV-19 vaccine, vaccine effectiveness among U.S. health care personnel, and a hot and tactile Nobel Prize; a review article on pulmonary arterial hypertension; a case report of a woman with abdominal pain, weight loss, and memory impairment; and Perspective articles on a failure to disseminate transformative science, on E66.01 and our culture of shame, and on Ms. Omega One. 

NEJM This Week — December 16, 2021

Featuring articles on tapinarof cream for psoriasis, dupilumab in children with asthma, the mRNA-1273 vaccine in adolescents, cardiovascular events with finerenone in kidney disease and type 2 diabetes, waning vaccine protection against SARS-CoV-2, and transgenic epidermis in junctional epidermolysis bullosa; a review article on latent tuberculosis infection; a case report of a man with fevers, fatigue, arthralgias, a mouth ulcer, and a rash; and Perspective articles on Covid-19 and the safety net and on inequitable access to hospital care. 

NEJM This Week — December 9, 2021

Featuring articles on debulking surgery in relapsed ovarian cancer, myocarditis after Covid-19 mRNA vaccine, edoxaban for atrial fibrillation with TAVR, milvexian for the prevention of venous thromboembolism, REGEN-COV in outpatients with acute SARS-CoV-2 infection, and a font of protein structures; a review article on spontaneous intracranial hypotension; a Clinical Problem-Solving describing a “fluid” diagnosis; and Perspective articles on using policy tools to improve population health, on decarbonizing the U.S. health sector, and on the web we weave. 

NEJM This Week — December 2, 2021

Featuring articles on spinal or general anesthesia for hip surgery, HIF-2α inhibition in von Hippel–Lindau disease, live birth after genetic testing for aneuploidy, belzutifan in the Pacak–Zhuang syndrome, and on responsible innovation in reproductive medicine; a review article on osteosarcoma; a case report of a man with pain and erythema of the left hand; and Perspective articles on why aducanumab is priced at $56,000 per patient, on Medicare coverage of aducanumab, and on the little things. 

NEJM This Week — November 25, 2021

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NEJM This Week — Audio Summaries

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